Structure of PDB 2jbp Chain D

Receptor sequence
>2jbpD (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ
DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGEL
FSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR
PNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG
YPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM
TITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE
3D structure
PDB2jbp Structural basis for a high affinity inhibitor bound to protein kinase MK2.
ChainD
Resolution3.31 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D138 K140 E142 N143 D159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O D L70 L72 G73 K93 L141 D142 L193 D207 L24 L26 G27 K47 L95 D96 L145 D159 BindingDB: IC50=8.5nM,EC50=49nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2jbp, PDBe:2jbp, PDBj:2jbp
PDBsum2jbp
PubMed17449059
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

[Back to BioLiP]