Structure of PDB 2i9p Chain D

Receptor sequence
>2i9pD (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
MPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSP
ADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAV
SKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELL
GCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKL
LAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLA
QDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLRE
3D structure
PDB2i9p Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
ChainD
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.31: 3-hydroxyisobutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G48 N49 M50 Y68 D69 V70 M102 L103 P104 N108 T134 V159 G161 F277 K284 G9 N10 M11 Y29 D30 V31 M63 L64 P65 N69 T95 V120 G122 F238 K245
Gene Ontology
Molecular Function
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:2i9p, PDBe:2i9p, PDBj:2i9p
PDBsum2i9p
PubMed
UniProtP31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial (Gene Name=HIBADH)

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