Structure of PDB 2i6a Chain D

Receptor sequence
>2i6aD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDEL
VKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRK
AAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDL
EKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFI
SQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALP
KMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF
VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
3D structure
PDB2i6a Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R132 G297 A298 G299 D300
Catalytic site (residue number reindexed from 1) R130 G295 A296 G297 D298
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5I5 D N14 D18 I39 C123 A136 F170 N296 D300 N12 D16 I37 C121 A134 F168 N294 D298 MOAD: ic50=0.9nM
BindingDB: IC50=9.0nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004001 adenosine kinase activity
GO:0004136 deoxyadenosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006175 dATP biosynthetic process
GO:0006753 nucleoside phosphate metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0032263 GMP salvage
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044209 AMP salvage
GO:0106383 dAMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2i6a, PDBe:2i6a, PDBj:2i6a
PDBsum2i6a
PubMed17154503
UniProtP55263|ADK_HUMAN Adenosine kinase (Gene Name=ADK)

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