Structure of PDB 2hk9 Chain D

Receptor sequence

>2hk9D (length=266) Species: 63363 (Aquifex aeolicus) [Search protein sequence]

MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKK
AFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKA
YGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVF
LWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIF
NYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIW
NGCEVPYSVAERSVRD

3D structure

PDB

2hk9 Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.25: shikimate dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	D	V67 K70 G130 A131 G132 G133 A134 N153 R154 T155 K158 T188 V190 I214 G235 M238 L239	V67 K70 G130 A131 G132 G133 A134 N153 R154 T155 K158 T188 V190 I214 G235 M238 L239
BS02	SKM	D	S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242	S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242

Gene Ontology

	Molecular Function
GO:0004764	shikimate 3-dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity
GO:0050661	NADP binding

	Biological Process
GO:0008652	amino acid biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process
GO:0009423	chorismate biosynthetic process
GO:0019632	shikimate metabolic process

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2hk9, PDBe:2hk9, PDBj:2hk9
PDBsum	2hk9
PubMed	17649975
UniProt	O67049\|AROE_AQUAE Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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