Structure of PDB 2h65 Chain D

Receptor sequence
>2h65D (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
KIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHI
LTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
3D structure
PDB2h65 Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Y204 S205 W206 R207 N208 S209 W214 S249 F250 Y19 S20 W21 R22 N23 S24 W29 S64 F65
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h65, PDBe:2h65, PDBj:2h65
PDBsum2h65
PubMed16781734
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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