Structure of PDB 2gm1 Chain D

Receptor sequence
>2gm1D (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLKSSRKTYT
FDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEG
ERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEE
LFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG
AAKRTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDLAGSENINQSL
LTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLN
LEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB2gm1 Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S232 S235 S215 S218
BS02 2AZ D E116 G117 E118 R119 W127 I136 P137 Y211 L214 E215 R221 E99 G100 E101 R102 W110 I119 P120 Y194 L197 E198 R204 MOAD: ic50=0.1uM
BindingDB: IC50=100nM
BS03 ADP D R26 P27 T107 G108 G110 K111 T112 F113 E118 R11 P12 T90 G91 G93 K94 T95 F96 E101
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2gm1, PDBe:2gm1, PDBj:2gm1
PDBsum2gm1
PubMed16730979
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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