Structure of PDB 2gl7 Chain D

Receptor sequence

>2gl7D (length=506) Species: 9606 (Homo sapiens) [Search protein sequence]

ELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVS
AIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS
PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAI
TTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKV
LSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQE
GMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEA
LVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVK
LLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD
TQRFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP
IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAA
AVLFRM

3D structure

PDB

2gl7 Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	F253 N261 K292 D299 Q302 Y306 K312 K335 W338 V346 V349 R386 N387 N426 C429 N430 K435 H470 R474 K508 G512 N516	F107 N115 K146 D153 Q156 Y160 K166 K189 W192 V200 V203 R240 N241 N280 C283 N284 K289 H324 R328 K362 G366 N370
BS02	peptide	D	L159 D164 V166 M174	L13 D18 V20 M28

Gene Ontology

	Molecular Function
GO:0045296	cadherin binding

	Biological Process
GO:0007155	cell adhesion

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2gl7, PDBe:2gl7, PDBj:2gl7
PDBsum	2gl7
PubMed	17052462
UniProt	P35222\|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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