Structure of PDB 2ffl Chain D

Receptor sequence
>2fflD (length=720) Species: 5741 (Giardia intestinalis) [Search protein sequence]
AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFE
AGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPR
FISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDEYTDYLS
ASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAH
NIHLRAADLPLVAAVRLDDLKDHQIPAPDDLAPKLRFLPPELCLLLPDEF
DLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGL
RLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCL
FPDASVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSKTWADMYEEIVG
SIFTGPNGIYGCEEFLAKTLMSPEHSKTACPDAVTKASKRVCMGEAGAHE
FRSLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQFSHR
SGLSVSVIDIMTHLARGLWLGSPGFYVEQPPTIPVLYIYHRSVQCPVLYG
SLTTGPVASKVLALYEKILAYEGSKHIAAQTVSRSLAVPIPSGTIPFLIR
LLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAE
TNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACG
EEAAGAFVREHVLPQVVADA
3D structure
PDB2ffl Structural Basis of Double-Stranded RNA Processing by Dicer
ChainD
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D E491 D495 E477 D481
BS02 MN D E649 D720 E723 E615 D686 E689
BS03 MN D E336 D404 E407 E332 D393 E396
BS04 MN D D653 E684 E723 D619 E650 E689
BS05 MN D E336 E673 E332 E639
BS06 MN D H610 Q614 H576 Q580
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing

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Molecular Function
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Biological Process
External links
PDB RCSB:2ffl, PDBe:2ffl, PDBj:2ffl
PDBsum2ffl
PubMed16410517
UniProtA8BQJ3|DCL_GIAIC Endoribonuclease Dicer-like (Gene Name=GL50803_103887)

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