Structure of PDB 2e9t Chain D

Receptor sequence

>2e9tD (length=474) Species: 244367 (Foot-and-mouth disease virus C-S8c1)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALE

3D structure

• PDB: 2e9t Sequential structures provide insights into the fidelity of RNA replication
• Chain: D
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	D109 T115 A116 R128 F162 V181 R193 H204 G216 C217 N218 G299 C300 S301 T303 Y336 I425 R461	D109 T115 A116 R128 F162 V181 R193 H204 G216 C217 N218 G299 C300 S301 T303 Y336 I425 R461
BS02	rna	D	Y336 D338 L386 K387 I411 R416 T419 E422 K423 S426 L430	Y336 D338 L386 K387 I411 R416 T419 E422 K423 S426 L430
BS03	MG	D	D238 D339 T384	D238 D339 T384

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:2e9t, PDBe:2e9t, PDBj:2e9t
• PDBsum: 2e9t
• PubMed: 17517631
• UniProt: Q9QCE4