Structure of PDB 2e77 Chain D

Receptor sequence
>2e77D (length=368) Species: 1377 (Aerococcus viridans) [Search protein sequence]
EYNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDR
AWKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHTTKEA
GTARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRD
ILDEAKSDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQRYLRGTA
EGMSLNNIYGASKQKISPRDIEEIAGHSGLPVFVKGIQHPEDADMAIKRG
ASGIWVSNHGARQLYEAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVA
KALASGADVVALGRPVLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQN
VEDLKGLDLFDNPYGYEY
3D structure
PDB2e77 Crystallographic study on the interaction of L-lactate oxidase with pyruvate at 1.9 Angstrom resolution.
ChainD
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S3122 Y3146 T3172 D3174 K3241 H3265
Catalytic site (residue number reindexed from 1) S116 Y140 T166 D168 K235 H259
Enzyme Commision number 1.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D P3093 I3094 A3095 S3122 Q3144 Y3146 T3172 K3241 H3265 G3266 R3268 D3296 S3297 G3298 R3300 G3319 R3320 P87 I88 A89 S116 Q138 Y140 T166 K235 H259 G260 R262 D290 S291 G292 R294 G313 R314
BS02 PYR D Y3040 Y3146 R3181 Y3215 H3265 R3268 Y34 Y140 R175 Y209 H259 R262
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2e77, PDBe:2e77, PDBj:2e77
PDBsum2e77
PubMed17517371
UniProtQ44467|LOX_AERVM L-lactate oxidase

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