Structure of PDB 2cml Chain D

Receptor sequence

>2cmlD (length=389) Species: 11320 (Influenza A virus)

RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRM
FALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSS
TSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESEC
VCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPND
PTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVP
NAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRG
RPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE

3D structure

• PDB: 2cml The Crystal Structure of Type a Influenza Virus Neuraminidase of the N6 Subtype Reveals the Existence of Two Separate Neu5Ac Binding Sites
• Chain: D
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D3157 E3284 R3299 R3378 Y3412
• Catalytic site (residue number reindexed from 1): D70 E197 R212 R291 Y325
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	D	P3397 I3398 N3400	P310 I311 N313
BS02	ZMR	D	R3124 E3125 D3157 R3158 W3185 E3234 A3253 E3283 R3299 R3378 Y3412	R37 E38 D70 R71 W98 E147 A166 E196 R212 R291 Y325
BS03	ZMR	D	S3374 S3377 S3379 N3406 Q3407 N3408 W3409	S287 S290 S292 N319 Q320 N321 W322
BS04	CA	D	D3300 G3304 D3331 P3354	D213 G217 D244 P267
BS05	MAN	D	P3397 N3400	P310 N313

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:2cml, PDBe:2cml, PDBj:2cml
• PDBsum: 2cml
• UniProt: Q6XV27|NRAM_I56A2 Neuraminidase (Gene Name=NA)