Structure of PDB 2cjf Chain D

Receptor sequence
>2cjfD (length=149) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
RSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTV
DFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLP
VVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG
3D structure
PDB2cjf Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases.
ChainD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.10: 3-dehydroquinate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RP4 D N616 L617 L619 R623 Y628 N679 A681 A682 H685 H706 I707 S708 R717 N15 L16 L18 R22 Y27 N78 A80 A81 H84 H105 I106 S107 R116 MOAD: Ki=380nM
Gene Ontology
Molecular Function
GO:0003855 3-dehydroquinate dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019631 quinate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2cjf, PDBe:2cjf, PDBj:2cjf
PDBsum2cjf
PubMed17487901
UniProtP15474|AROQ_STRCO 3-dehydroquinate dehydratase (Gene Name=aroQ)

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