Structure of PDB 2cdb Chain D

Receptor sequence
>2cdbD (length=359) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGADREIVNGKL
GKDFLVLGHEAIGVVEESYHGFSQGDLVMPVNRRGCGICRNCLVGRPDFC
ETGEFGEAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADIEK
SIEEILEVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFTLLFRTYGLEV
WMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGAD
VNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLVN
GQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEHG
EIKIRILWE
3D structure
PDB2cdb The Structural Basis of Substrate Promiscuity in Glucose Dehydrogenase from the Hyperthermophilic Archaeon Sulfolobus Solfataricus.
ChainD
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.120: galactose 1-dehydrogenase (NADP(+)).
1.1.1.359: aldose 1-dehydrogenase [NAD(P)(+)].
1.1.1.47: glucose 1-dehydrogenase [NAD(P)(+)].
1.1.1.48: D-galactose 1-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC D E114 Q150 D154 N307 E107 Q143 D147 N300
BS02 NAP D G188 T189 G190 P191 I192 N211 R212 R213 A253 T254 F277 G278 F279 V306 K354 G181 T182 G183 P184 I185 N204 R205 R206 A246 T247 F270 G271 F272 V299 K347
BS03 ZN D C39 H66 E67 C39 H59 E60
BS04 ZN D C93 C96 C99 C107 C86 C89 C92 C100
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005534 galactose binding
GO:0005536 D-glucose binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019151 galactose 1-dehydrogenase activity
GO:0033222 xylose binding
GO:0046872 metal ion binding
GO:0047640 aldose 1-dehydrogenase activity
GO:0047910 galactose 1-dehydrogenase (NADP+) activity
GO:0047934 glucose 1-dehydrogenase (NAD+) activity
GO:0047935 glucose 1-dehydrogenase (NADP+) activity
GO:0047936 glucose 1-dehydrogenase [NAD(P)+] activity
GO:0070401 NADP+ binding
GO:0070403 NAD+ binding
Biological Process
GO:0019595 non-phosphorylated glucose catabolic process
GO:0033498 galactose catabolic process via D-galactonate
GO:0051262 protein tetramerization

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2cdb, PDBe:2cdb, PDBj:2cdb
PDBsum2cdb
PubMed16556607
UniProtO93715|GLCDH_SACSO Glucose 1-dehydrogenase (Gene Name=gdh)

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