Structure of PDB 2c91 Chain D

Receptor sequence
>2c91D (length=324) Species: 10090 (Mus musculus) [Search protein sequence]
LRPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENI
LGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRV
DLFYLHAPDHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLC
KSNGWILPTVYQGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTG
KYKYEDKDGKQPVGRFFGNNWAETYRNRFWKEHHFEAIALVEKALQTTYG
TNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPL
EPAVVEAFDQAWNMVAHECPNYFR
3D structure
PDB2c91 Crystal Structure of Mouse Succinic Semialdehyde Reductase Akr7A5: Structural Basis for Substrate Specificity.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.n11: succinic semialdehyde reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G11 T12 M13 R18 D40 Y45 Q165 Y193 N194 P195 L196 G198 G199 T202 K204 R218 I282 G284 M285 S286 Q290 Q293 N294 G8 T9 M10 R15 D37 Y42 Q162 Y190 N191 P192 L193 G195 G196 T199 K201 R215 I279 G281 M282 S283 Q287 Q290 N291
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus

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Cellular Component
External links
PDB RCSB:2c91, PDBe:2c91, PDBj:2c91
PDBsum2c91
PubMed16460003
UniProtQ8CG76|ARK72_MOUSE Aflatoxin B1 aldehyde reductase member 2 (Gene Name=Akr7a2)

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