Structure of PDB 2c7v Chain D

Receptor sequence
>2c7vD (length=257) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVQGDHNGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGSSNLSIVNLCD
AMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPV
AMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDG
GLSLVHA
3D structure
PDB2c7v Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R14 D161 Y174 K178
Catalytic site (residue number reindexed from 1) R13 D150 Y163 K167
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 C160 K178 P204 G205 S207 R13 I14 H32 Y33 H34 N35 S36 D61 L62 N92 A93 S94 T121 C149 K167 P193 G194 S196
BS02 MTX D R14 S95 F97 P99 Y174 L208 P210 M213 W221 R13 S94 F96 P98 Y163 L197 P199 M202 W210 MOAD: Ki=152nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity

View graph for
Molecular Function
External links
PDB RCSB:2c7v, PDBe:2c7v, PDBj:2c7v
PDBsum2c7v
PubMed16968221
UniProtO76290

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