Structure of PDB 2bme Chain D

Receptor sequence
>2bmeD (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
SETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIIN
VGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTN
WLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETS
ALTGENVEEAFVQCARKILNKIES
3D structure
PDB2bme High Resolution Crystal Structures of Human Rab4A in its Active and Inactive Conformations.
ChainD
Resolution1.57 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q69
Catalytic site (residue number reindexed from 1) Q66
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D G20 G22 K23 S24 C25 F35 S39 H41 T42 G68 N123 K124 D126 L127 S153 A154 L155 G17 G19 K20 S21 C22 F32 S36 H38 T39 G65 N120 K121 D123 L124 S150 A151 L152
BS02 MG D S24 T42 S21 T39
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0032482 Rab protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2bme, PDBe:2bme, PDBj:2bme
PDBsum2bme
PubMed15907487
UniProtP20338|RAB4A_HUMAN Ras-related protein Rab-4A (Gene Name=RAB4A)

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