Structure of PDB 2bht Chain D

Receptor sequence
>2bhtD (length=285) Species: 562 (Escherichia coli) [Search protein sequence]
MSTLEQTIGNTPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIV
EAEKRGRIKPGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDERRAAMR
AYGAELIMEGARDLALEMANRGEGKLLDQFNNPDNPKAHYTTTGPEIWQQ
TGGRITHFVSSMGTTGTITGVSEFMREQSKPVTIVGLQPEEGSSIPGIRR
WPTEYLPGIFNASLVDEVLDIHQRDAENTMRELAVREGIFCGVSSGGAVA
GALRVAKANPDAVVVAIICDRGDRYLSTGVFGEEH
3D structure
PDB2bht Structure of the O-Acetylserine Sulfhydrylase Isoenzyme Cysm from Escherichia Coli
ChainD
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K41 S69 Q199 G203 S255 C280
Catalytic site (residue number reindexed from 1) K41 S69 Q188 G192 S244 C269
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP D V40 K41 G174 T175 T176 T178 G208 S255 C280 V40 K41 G163 T164 T165 T167 G197 S244 C269
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0016226 iron-sulfur cluster assembly
GO:0019344 cysteine biosynthetic process
GO:0019345 cysteine biosynthetic process via S-sulfo-L-cysteine
GO:0019450 L-cysteine catabolic process to pyruvate
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2bht, PDBe:2bht, PDBj:2bht
PDBsum2bht
PubMed15952768
UniProtP16703|CYSM_ECOLI Cysteine synthase B (Gene Name=cysM)

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