Structure of PDB 2bhs Chain D

Receptor sequence
>2bhsD (length=291) Species: 562 (Escherichia coli) [Search protein sequence]
STLEQTIGNTPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIVE
AEKRGEIKPGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRA
AMRAYGAELILVTKEQGMEGARDLALEMANRGEGKLLDQFNNPDNPYAHY
TTTGPEIWQQTGGRITHFVSSMGTTGTITGVSRFMREQSKPVTIVGLQPE
EGSSIPGIRRWPTEYLPGIFNASLVDEVLDIHQRDAENTMRELAVREGIF
CGVSSGGAVAGALRVAKANPDAVVVAIICDRGDRYLSTGVF
3D structure
PDB2bhs Structure of the O-Acetylserine Sulfhydrylase Isoenzyme Cysm from Escherichia Coli
ChainD
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K41 S69 Q199 G203 S255 C280
Catalytic site (residue number reindexed from 1) K40 S68 Q198 G202 S254 C279
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP D K41 N71 G174 T175 T176 G177 T178 G208 S255 C280 K40 N70 G173 T174 T175 G176 T177 G207 S254 C279
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0016226 iron-sulfur cluster assembly
GO:0019344 cysteine biosynthetic process
GO:0019345 cysteine biosynthetic process via S-sulfo-L-cysteine
GO:0019450 L-cysteine catabolic process to pyruvate
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2bhs, PDBe:2bhs, PDBj:2bhs
PDBsum2bhs
PubMed15952768
UniProtP16703|CYSM_ECOLI Cysteine synthase B (Gene Name=cysM)

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