Structure of PDB 2aob Chain D

Receptor sequence
>2aobD (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHF
KVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDI
3D structure
PDB2aob Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
ChainD
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S1S D W121 V122 F125 E130 Y134 W63 V64 F67 E72 Y76
BS02 S1S D S127 L128 S69 L70
BS03 S1S D R67 R86 S96 H107 F108 K109 L111 L120 W121 R9 R28 S38 H49 F50 K51 L53 L62 W63
External links
PDB RCSB:2aob, PDBe:2aob, PDBj:2aob
PDBsum2aob
PubMed16165154
UniProtP62993|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)

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