Structure of PDB 2ahr Chain D

Receptor sequence
>2ahrD (length=258) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence]
NAMKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLALPYA
MSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATF
VGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTF
DISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGIPKAKALEIVTQTV
LASASNLKTSSQSPHDFIDAICSPGGTTIAGLMELERLGLTATVSSAIDK
TIDKAKSL
3D structure
PDB2ahr Crystal Structures of Delta(1)-Pyrroline-5-carboxylate Reductase from Human Pathogens Neisseria meningitides and Streptococcus pyogenes
ChainD
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.2: pyrroline-5-carboxylate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D I219 S221 I221 S223
BS02 NAP D V8 G9 K10 M11 G30 S31 R35 H51 I65 P67 L69 V73 M86 A87 A88 M109 M112 V10 G11 K12 M13 G32 S33 R37 H53 I67 P69 L71 V75 M88 A89 A90 M111 M114
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006561 proline biosynthetic process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2ahr, PDBe:2ahr, PDBj:2ahr
PDBsum2ahr
PubMed16233902
UniProtQ9A1S9

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