Structure of PDB 1zm4 Chain D

Receptor sequence
>1zm4D (length=207) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EFLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQ
SIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGAL
LRVYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEE
GGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALP
DYASQPG
3D structure
PDB1zm4 Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
ChainD
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E155
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAD D H440 G441 T442 A446 S449 I450 V455 R456 Y470 Y481 E553 H42 G43 T44 A48 S51 I52 V57 R58 Y72 Y83 E155
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1zm4, PDBe:1zm4, PDBj:1zm4
PDBsum1zm4
PubMed16107839
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

[Back to BioLiP]