Structure of PDB 1zbh Chain D

Receptor sequence
>1zbhD (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNY
YKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLL
NTHTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKK
VIDLMKLKELGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWIN
IRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPNCGLDDSKNIARIAVRM
LQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFR
3D structure
PDB1zbh Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
ChainD
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D134 E136 D234 N293 D298
Catalytic site (residue number reindexed from 1) D75 E77 D175 N234 D239
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D F61 Y66 K67 A70 N73 G74 N77 R78 K104 K107 K111 F2 Y7 K8 A11 N14 G15 N18 R19 K45 K48 K52
BS02 rna D K262 N266 K269 P271 R272 S332 K203 N207 K210 P212 R213 S273
BS03 MG D D134 E136 D298 D75 E77 D239
BS04 AMP D D134 E136 A137 C139 N143 F185 F238 D75 E77 A78 C80 N84 F126 F179
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:1zbh, PDBe:1zbh, PDBj:1zbh
PDBsum1zbh
PubMed
UniProtQ8IV48|ERI1_HUMAN 3'-5' exoribonuclease 1 (Gene Name=ERI1)

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