Structure of PDB 1z9h Chain D

Receptor sequence
>1z9hD (length=274) Species: 9541 (Macaca fascicularis) [Search protein sequence]
LQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVLRAEIKFSSYRKVP
ILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNDQG
KEVTEFGNKYWLMLNEKEAQQVYSGKEARTEEMKWRQWADDWLVHLISPN
VYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRL
QDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDA
FDDLMQHTHIQPWYLRVERAITEA
3D structure
PDB1z9h Crystal Structure and Possible Catalytic Mechanism of Microsomal Prostaglandin E Synthase Type 2 (mPGES-2).
ChainD
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y107 C110 F112 C113
Catalytic site (residue number reindexed from 1) Y8 C11 F13 C14
Enzyme Commision number 5.3.99.3: prostaglandin-E synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMN D Y107 T109 C110 P111 F112 P134 I246 Y251 S260 Y263 V343 Y8 T10 C11 P12 F13 P35 I147 Y152 S161 Y164 V244
Gene Ontology
Molecular Function
GO:0050220 prostaglandin-E synthase activity

View graph for
Molecular Function
External links
PDB RCSB:1z9h, PDBe:1z9h, PDBj:1z9h
PDBsum1z9h
PubMed15854652
UniProtQ9N0A4|PGES2_MACFA Prostaglandin E synthase 2 (Gene Name=PTGES2)

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