Structure of PDB 1wyu Chain D

Receptor sequence
>1wyuD (length=473) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
SFPLIFERSRKGRRGLKLVKAVPKAEDLIPKEHLREVPPRLPEVDELTLV
RHYTGLSRRQVGVDTTFYPLGSCTMKYNPKLHEEAARLFADLHPYQDPRT
AQGALRLMWELGEYLKALTGMDAITLEPAAGAHGELTGILIIRAYHEDRG
EGRTRRVVLVPDSAHGSNPATASMAGYQVREIPSGPEGEVDLEALKRELG
PHVAALMLTNPNTLGLFERRILEISRLCKEAGVQLYYDGANLNAIMGWAR
PGDMGFDVVHLNLHKTFTVPHGGGGPGSGPVGVKAHLAPYLPVPLVERGE
EGFYLDFDRPKSIGRVRSFYGNFLALVRAWAYIRTLGLEGLKKAAALAVL
NARYLKELLKEKGYRVPYDGPSMHEFVAQPPEGFRALDLAKGLLELGFHP
PTVYFPLIVKEALMVEPTETEAKETLEAFAEAMGALLKKPKEWLENAPYS
TPVRRLDELRANKHPKLTYFDEG
3D structure
PDB1wyu Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia
ChainD
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP D S73 A131 G132 A133 H166 D239 A241 N263 H265 K266 S72 A130 G131 A132 H165 D238 A240 N262 H264 K265
Gene Ontology
Molecular Function
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0016594 glycine binding
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
Cellular Component
GO:0005829 cytosol
GO:0005960 glycine cleavage complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1wyu, PDBe:1wyu, PDBj:1wyu
PDBsum1wyu
PubMed15791207
UniProtQ5SKW7|GCSPB_THET8 Probable glycine dehydrogenase (decarboxylating) subunit 2 (Gene Name=gcvPB)

[Back to BioLiP]