Structure of PDB 1w21 Chain D

Receptor sequence

>1w21D (length=389) Species: 11320 (Influenza A virus)

RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRM
FALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSS
TSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESEC
VCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPND
PTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVP
NAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRG
RPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE

3D structure

• PDB: 1w21 The Crystal Structure of Type a Influenza Virus Neuraminidase of the N6 Subtype Reveals the Existence of Two Separate Neu5Ac Binding Sites
• Chain: D
• Resolution: 2.08 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D3157 E3284 R3299 R3378 Y3412
• Catalytic site (residue number reindexed from 1): D70 E197 R212 R291 Y325
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	D	I3398 S3399 N3400	I311 S312 N313
BS02	SIA	D	E3125 D3157 A3253 E3283 E3284 R3299 R3378 Y3412	E38 D70 A166 E196 E197 R212 R291 Y325
BS03	SIA	D	S3374 S3377 S3379 N3406 N3408 W3409	S287 S290 S292 N319 N321 W322
BS04	CA	D	D3300 G3304 D3331 P3354	D213 G217 D244 P267

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:1w21, PDBe:1w21, PDBj:1w21
• PDBsum: 1w21
• UniProt: Q6XV27|NRAM_I56A2 Neuraminidase (Gene Name=NA)