Structure of PDB 1tz2 Chain D

Receptor sequence

>1tz2D (length=329) Species: 74568 (Pseudomonas sp. ACP)

MNLQRFPRYPLTFGPTPIQPLARLSKHLGGKVHLYAKREDCNSGLAFGGN
KTRKLEYLIPEALAQGCDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQE
NWVNYSDAVYDRVGNIQMSRILGADVRLVRSWEDALESVRAAGGKPYAIP
AGCSDHPLGGLGFVGFAEEVRAQEAELGFKFDYVVVCSVTGSTQAGMVVG
FAADGRADRVIGVDASAKPAQTREQITRIARQTAEKVGLERDIMRADVVL
DERFAGPEYGLPNEGTLEAIRLCARTEGMLTDPVYEGKSMHGMIEMVRNG
EFPEGSRVLYAHLGGVPALNGYSFIFRDG

3D structure

• PDB: 1tz2 Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction
• Chain: D
• Resolution: 2.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K51 Y268 Y294
• Catalytic site (residue number reindexed from 1): K51 Y259 Y285
• Enzyme Commision number: 3.5.99.7: 1-aminocyclopropane-1-carboxylate deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	D	N50 K51 K54 N79 C196 S197 V198 T199 G200 T202 Y294 E295 L322 G323 G324	N50 K51 K54 N79 C187 S188 V189 T190 G191 T193 Y285 E286 L313 G314 G315
BS02	1AC	D	K51 S78 N79 Q80 T199 Y294	K51 S78 N79 Q80 T190 Y285

Gene Ontology

Molecular Function

• GO:0008660 1-aminocyclopropane-1-carboxylate deaminase activity
• GO:0016787 hydrolase activity
• GO:0019148 D-cysteine desulfhydrase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009310 amine catabolic process
• GO:0018871 1-aminocyclopropane-1-carboxylate metabolic process

External links

• PDB: RCSB:1tz2, PDBe:1tz2, PDBj:1tz2
• PDBsum: 1tz2
• PubMed: 15491139
• UniProt: Q00740|1A1D_PSEUD 1-aminocyclopropane-1-carboxylate deaminase (Gene Name=acdS)