Structure of PDB 1sq5 Chain D

Receptor sequence
>1sq5D (length=304) Species: 562 (Escherichia coli) [Search protein sequence]
MTPYLQFDRNQWAALRDMTLSEDEIARLKGINEDLSLEEVAEIYLPLSRL
LNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQAL
LSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVS
DLKSGVPNVTAPVYSHLIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPH
DPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNY
AKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSANHAVEEV
RLRK
3D structure
PDB1sq5 The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
ChainD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU D D4127 K4145 G4146 Y4240 I4281 N4282 D116 K134 G135 Y228 I269 N270
BS02 ADP D N4043 A4098 G4100 K4101 S4102 T4103 R4243 K4303 H4307 N32 A87 G89 K90 S91 T92 R231 K291 H295
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1sq5, PDBe:1sq5, PDBj:1sq5
PDBsum1sq5
PubMed15136582
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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