Structure of PDB 1shr Chain D

Receptor sequence
>1shrD (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
VHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSS
PDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDP
ENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH
3D structure
PDB1shr Crystal structures of HbA2 and HbE and modeling of hemoglobin delta4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb
ChainD
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYN D K82 H146 K82 H146
BS02 CYN D H63 V67 H63 V67
BS03 CYN D K82 H143 K82 H143
BS04 HEM D T38 F41 F42 H63 L88 H92 L96 V98 N102 F103 L106 L141 T38 F41 F42 H63 L88 H92 L96 V98 N102 F103 L106 L141
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0005344 oxygen carrier activity
GO:0005515 protein binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0031720 haptoglobin binding
GO:0031721 hemoglobin alpha binding
GO:0043177 organic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0015670 carbon dioxide transport
GO:0015671 oxygen transport
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0031838 haptoglobin-hemoglobin complex
GO:0072562 blood microparticle

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Cellular Component
External links
PDB RCSB:1shr, PDBe:1shr, PDBj:1shr
PDBsum1shr
PubMed15449937
UniProtP02042|HBD_HUMAN Hemoglobin subunit delta (Gene Name=HBD)

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