Structure of PDB 1s4d Chain D

Receptor sequence
>1s4dD (length=248) Species: 43306 (Pseudomonas denitrificans (nom. rej.)) [Search protein sequence]
AGLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCLK
LARPGAVLEFAGPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFGRGGE
EALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTGHDSS
GRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAAT
PQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGALDG
3D structure
PDB1s4d Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D47 M184
Catalytic site (residue number reindexed from 1) D41 M169
Enzyme Commision number 2.1.1.107: uroporphyrinogen-III C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D G100 G101 D102 V105 F106 T130 A131 Y183 M184 N212 A213 P240 A241 I242 G89 G90 D91 V94 F95 T119 A120 Y168 M169 N197 A198 P225 A226 I227
Gene Ontology
Molecular Function
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s4d, PDBe:1s4d, PDBj:1s4d
PDBsum1s4d
PubMed15522295
UniProtP21631|SUMT_SINSX Uroporphyrinogen-III C-methyltransferase (Gene Name=cobA)

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