Structure of PDB 1rd4 Chain D

Receptor sequence
>1rd4D (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVIEG
3D structure
PDB1rd4 Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L08 D F153 Y166 I235 Y257 I259 E284 F285 V286 K287 L298 E301 L302 K305 F26 Y39 I108 Y130 I132 E157 F158 V159 K160 L171 E174 L175 K178 MOAD: Kd=18.3nM
BindingDB: Kd=18nM
External links
PDB RCSB:1rd4, PDBe:1rd4, PDBj:1rd4
PDBsum1rd4
PubMed14992576
UniProtP20701|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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