Structure of PDB 1r0z Chain D

Receptor sequence
>1r0zD (length=259) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGEFSHLCLVGNPVLKNINLNIEKGEMLAITGSTG
SGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENIIFGVS
YDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLARA
VYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLR
KADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSI
LTETLRRFS
3D structure
PDB1r0z Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
ChainD
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D T465 Q493 T54 Q82
BS02 ATP D W401 F430 G461 S462 G463 K464 T465 S466 Q493 W12 F19 G50 S51 G52 K53 T54 S55 Q82
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0z, PDBe:1r0z, PDBj:1r0z
PDBsum1r0z
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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