Structure of PDB 1r0x Chain D

Receptor sequence
>1r0xD (length=263) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKFSHLCLVGNPVLKNINLNIEKGEMLAIT
GSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENII
FGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARIS
LARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKM
EHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEER
RSSILTETLRRFS
3D structure
PDB1r0x Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
ChainD
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D T465 Q493 T58 Q86
BS02 ATP D W401 V440 G461 S462 G463 K464 T465 S466 Q493 W12 V33 G54 S55 G56 K57 T58 S59 Q86 MOAD: Kd=149uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0x, PDBe:1r0x, PDBj:1r0x
PDBsum1r0x
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

[Back to BioLiP]