Structure of PDB 1qzu Chain D

Receptor sequence
>1qzuD (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
RKFHVLVGVTGSVAALKLPLLVSKLLGLEVAVVTTERAKHFYSPQDIPVT
LYSDADEWEMWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDN
LLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPVGT
IVDKV
3D structure
PDB1qzu Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase.
ChainD
Resolution2.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H88
Catalytic site (residue number reindexed from 1) H70
Enzyme Commision number 4.1.1.36: phosphopantothenoylcysteine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D T25 G26 S27 V28 T53 F59 D104 A105 N106 A138 M139 M143 T10 G11 S12 V13 T35 F41 D86 A87 N88 A120 M121 M125
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0005515 protein binding
GO:0010181 FMN binding
GO:0016831 carboxy-lyase activity
GO:0042802 identical protein binding
Biological Process
GO:0015937 coenzyme A biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0071513 phosphopantothenoylcysteine decarboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1qzu, PDBe:1qzu, PDBj:1qzu
PDBsum1qzu
PubMed14501115
UniProtQ96CD2|COAC_HUMAN Phosphopantothenoylcysteine decarboxylase (Gene Name=PPCDC)

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