Structure of PDB 1qxo Chain D

Receptor sequence
>1qxoD (length=388) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRMK
IENDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSK
RKITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLL
AELDMEIANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEI
KDYIDQIKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSI
NAFKGVEFGLGFEAGYRKGSQVMDEILWSKEDGYTRRTNNLGGFEGGMTN
GQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKATVERSDPTALPAAGMVM
EAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY
3D structure
PDB1qxo The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.5: chorismate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D H110 A133 N251 A252 M310 K311 I313 P314 T315 S338 H110 A133 N251 A252 M310 K311 I313 P314 T315 S338 MOAD: Kd=20nM
BindingDB: Kd=>20000nM
BS02 FMN D E263 Y266 E263 Y266 MOAD: Kd=20nM
BindingDB: Kd=>20000nM
BS03 EPS D R39 R45 R48 M49 S132 A133 R134 R337 R39 R45 R48 M49 S132 A133 R134 R337
Gene Ontology
Molecular Function
GO:0004107 chorismate synthase activity
GO:0010181 FMN binding
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1qxo, PDBe:1qxo, PDBj:1qxo
PDBsum1qxo
PubMed14656434
UniProtP0A2Y6|AROC_STRPN Chorismate synthase (Gene Name=aroC)

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