Structure of PDB 1qi1 Chain D

Receptor sequence
>1qi1D (length=474) Species: 1309 (Streptococcus mutans) [Search protein sequence]
TKQYKNYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKK
AQPAWRALSYIERAAYLHKVADILMRDKEKIGAILSKEVAKGYKSAVSEV
VRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAIS
PFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAG
VFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAGMRPIMLEL
GGKDSAIVLEDADLELTAKNIIAGAFGYSGQRSTAVKRVLVMESVADELV
EKIREKVLALTIGNPEDDADITPLIDTKSADYVEGLINDANDKGATALTE
IKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKS
EYGLQASIFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSG
AGIQGVKYSIEAMTTVKSVVFDIK
3D structure
PDB1qi1 Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.
ChainD
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N154 K177 E250 S284 E377 Q455
Catalytic site (residue number reindexed from 1) N153 K176 E249 S283 E376 Q454
Enzyme Commision number 1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D P152 F153 N154 P179 T180 G214 F228 G230 S231 I234 E250 L251 G252 S284 F379 P151 F152 N153 P178 T179 G213 F227 G229 S230 I233 E249 L250 G251 S283 F378
BS02 G3H D Y155 R283 S284 T285 Q436 R437 Y154 R282 S283 T284 Q435 R436
Gene Ontology
Molecular Function
GO:0008886 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
GO:0008911 lactaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity

View graph for
Molecular Function
External links
PDB RCSB:1qi1, PDBe:1qi1, PDBj:1qi1
PDBsum1qi1
PubMed10864505
UniProtQ59931|GAPN_STRMU NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gapN)

[Back to BioLiP]