Structure of PDB 1q74 Chain D

Receptor sequence
>1q74D (length=278) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVHVVTCTLGEEGEVIGD
RWAQLTADHADQLGGYRIGELTAALRALGVSAPIYLGGAGRWRDSGMAQR
SQRRFVDADPRQTVGALVAIIRELRPHVVVTYDPNGGYGHPDHVHTHTVT
TAAVAAAGVADHPGDPWTVPKFYWTVLGLSALISGARALVPDDLRPGYSD
DGIDAVVEADEQARAAKVAALAAHATQVVVGPTGRAAALSNNLALPILAD
EHYVLAGGSAGARDERGWETDLLAGLGF
3D structure
PDB1q74 The Crystal Structure of 1-D-myo-Inositol 2-Acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold.
ChainD
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.103: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H13 D16 H147 H12 D15 H143
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0019213 deacetylase activity
GO:0035595 N-acetylglucosaminylinositol deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0010125 mycothiol biosynthetic process
GO:0016137 glycoside metabolic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1q74, PDBe:1q74, PDBj:1q74
PDBsum1q74
PubMed12958317
UniProtP9WJN3|MSHB_MYCTU 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (Gene Name=mshB)

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