Structure of PDB 1pq6 Chain D

Receptor sequence
>1pq6D (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LTAAQELMIQQLVAAQLQCNKRSFSKVTPWPLARQQRFAHFTELAIISVQ
EIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFL
KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS
ADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRT
LSSVHSEQVFALRLKLPPLLSEIWDVH
3D structure
PDB1pq6 The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 965 D F271 L274 S278 I309 M312 L313 T316 R319 F329 L330 F340 F349 I353 F354 H435 W457 F41 L44 S48 I79 M82 L83 T86 R89 F99 L100 F110 F119 I123 F124 H205 W224 BindingDB: EC50=40.0nM,IC50=23nM,Ki=2.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1pq6, PDBe:1pq6, PDBj:1pq6
PDBsum1pq6
PubMed12819202
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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