Structure of PDB 1p8j Chain D

Receptor sequence

>1p8jD (length=467) Species: 10090 (Mus musculus)

VYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
DDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEP
KDIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEAN
NYGTLTKFTLVLYGTAP

3D structure

• PDB: 1p8j The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
• Chain: D
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D153 H194
• Catalytic site (residue number reindexed from 1): D45 H86
• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y495 N496 Y560	Y387 N388 Y452
BS02	peptide	D	D154 H194 E236 S253 W254 G255 P256 D258 D264 G294 N295 D306 Y308 S368	D46 H86 E128 S145 W146 G147 P148 D150 D156 G186 N187 D198 Y200 S260
BS03	peptide	D	H194 S368	H86 S260
BS04	CA	D	D115 D162 V205 N208 V210 G212	D7 D54 V97 N100 V102 G104
BS05	CA	D	D258 D301 E331	D150 D193 E223

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1p8j, PDBe:1p8j, PDBj:1p8j
• PDBsum: 1p8j
• PubMed: 12794637
• UniProt: P23188|FURIN_MOUSE Furin (Gene Name=Furin)