Structure of PDB 1mx0 Chain D

Receptor sequence
>1mx0D (length=461) Species: 2286 (Saccharolobus shibatae) [Search protein sequence]
KEKFTSLSPAEFFKRNPELAGFPNPARALYQTVRELIENSLDATDVHGIL
PNIKITIDLIDDARQIYKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQ
TRGMYGLGVKAAVLYSQMHQDKPIEIETSPVNSKRIYTFKLKIDINKNEP
IIVERGSVENTRGFHGTSVAISIPGDWPKAKSRIYEYIKRTYIITPYAEF
IFKDPEGNVTYYPRLTNKIPKPPQEVKPHPYGVDREEIKILINNLKRDYT
IKEFLVNEFQSIGDTTADKILELAGLKPNKKVKNLTEEEITRLVETFKKY
EDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQGHPFIVE
AGVAFGGSIPVGEEPIVLRYANKIPLIYDEKSDVIWKVVEELDWKRYGIE
SDQYQMVVMVHLCSTKIPYKSAGKESIAEVEDIEKEIKNALMEVARKLKQ
YLSEKRKEQEA
3D structure
PDB1mx0 Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D N42 A46 I81 A89 S96 S97 K98 G106 M107 Y108 G109 L110 G111 V112 K113 K427 N39 A43 I78 A86 S93 S94 K95 G103 M104 Y105 G106 L107 G108 V109 K110 K424
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:1mx0, PDBe:1mx0, PDBj:1mx0
PDBsum1mx0
PubMed12505993
UniProtO05207|TOP6B_SACSH Type 2 DNA topoisomerase 6 subunit B (Gene Name=top6B)

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