Structure of PDB 1m2z Chain D

Receptor sequence
>1m2zD (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
LPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAA
VKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFA
PDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSS
VPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDS
MHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLF
HQK
3D structure
PDB1m2z Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D K579 R585 M593 Q597 E755 T758 N759 K55 R61 M69 Q73 E231 T234 N235
BS02 DEX D N564 Q570 M601 M604 F623 Q642 M646 C736 T739 N40 Q46 M77 M80 F99 Q118 M122 C212 T215 BindingDB: EC50=2.5nM,Ki=1.2nM,IC50=5nM,Kd=19nM
External links
PDB RCSB:1m2z, PDBe:1m2z, PDBj:1m2z
PDBsum1m2z
PubMed12151000
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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