Structure of PDB 1l7e Chain D

Receptor sequence
>1l7eD (length=367) Species: 1085 (Rhodospirillum rubrum) [Search protein sequence]
MKIAIPKERRPGEDRVAISPEVVKKLVGLGFEVIVEQGAGVGASITDDAL
TAAGATIASTAAQALSQADVVWKVQRPMTAEEGTDEVALIKEGAVLMCHL
GALTNRPVVEALTKRKITAYAMELMPRISRAQSMDILSSQSNLAGYRAVI
DGAYEFARAFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMA
TDVRAATKEQVESLGGKFITVDGGYAKEMGEEFRKKQAEAVLKELVKTDI
AITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGGNCPLSEPGKIV
VKHGVKIVGHTNVPSRVAADASPLFAKNLLNFLTPHVDKDTKTLVMKLED
ETVSGTCVTRDGAIVHP
3D structure
PDB1l7e Crystal Structures of Transhydrogenase Domain I with and without Bound NADH
ChainD
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R1215 Q1275 H1299 G1301 E1323 R1327 Q1332 D1335 S1338 Y1435 E1496
Catalytic site (residue number reindexed from 1) R15 Q75 H99 G101 E123 R127 Q132 D135 S138 Y225 E286
Enzyme Commision number 7.1.1.1: proton-translocating NAD(P)(+) transhydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI D R1327 I1328 Q1332 D1335 S1338 G1381 D1402 R1404 A1436 Q1447 A1465 L1466 P1473 L1475 R127 I128 Q132 D135 S138 G181 D202 R204 A226 Q237 A255 L256 P263 L265
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003957 NAD(P)+ transhydrogenase (Si-specific) activity
GO:0005515 protein binding
GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
GO:0070404 NADH binding
Biological Process
GO:0006740 NADPH regeneration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1l7e, PDBe:1l7e, PDBj:1l7e
PDBsum1l7e
PubMed12379117
UniProtQ2RSB2|PNTAA_RHORT NAD(P) transhydrogenase subunit alpha part 1 (Gene Name=pntAA)

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