Structure of PDB 1kkq Chain D

Receptor sequence
>1kkqD (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM
AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFAN
LDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRK
PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKK
TESDAALHPLLQEIYRDMY
3D structure
PDB1kkq Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R209 E212 K216 T288 E289 K292 V306 Y314 R10 E13 K17 T89 E90 K93 V107 Y115
BS02 471 D L254 I272 F273 C276 S280 Y314 V332 F351 L55 I73 F74 C77 S81 Y115 V133 F152
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kkq, PDBe:1kkq, PDBj:1kkq
PDBsum1kkq
PubMed11845213
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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