Structure of PDB 1jq3 Chain D

Receptor sequence
>1jq3D (length=293) Species: 2336 (Thermotoga maritima) [Search protein sequence]
LKELERELQPRQHLWYFEYYTGNNVGLFMKMNRVIYSGQSDIQRIDIFEN
PDLGVVFALDGITMTTEKDEFMYHEMLAHVPMFLHPNPKKVLIIGGGDGG
TLREVLKHDSVEKAILCEVDGLVIEAARKYLKQTSCGFDDPRAEIVIANG
AEYVRKFKNEFDVIIIDSTDPTAGQGGHLFTEEFYQACYDALKEDGVFSA
ETEDPFYDIGWFKLAYRRISKVFPITRVYLGFMTTYPSGMWSYTFASKGI
DPIKDFDPEKVRKFNKELKYYNEEVHVASFALPNFVKKELGLM
3D structure
PDB1jq3 The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
ChainD
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AAT D L62 M67 Y76 H77 G98 D101 E121 V122 N152 G153 D170 S171 T172 G177 Q178 L182 Y239 L59 M64 Y73 H74 G95 D98 E118 V119 N149 G150 D167 S168 T169 G174 Q175 L179 Y236 MOAD: ic50=0.2uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0010487 thermospermine synthase activity
GO:0016740 transferase activity
GO:0043918 cadaverine aminopropyltransferase activity
GO:0043919 agmatine aminopropyltransferase activity
GO:0050314 sym-norspermidine synthase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jq3, PDBe:1jq3, PDBj:1jq3
PDBsum1jq3
PubMed11731804
UniProtQ9WZC2|SPEE_THEMA Polyamine aminopropyltransferase (Gene Name=speE)

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