Structure of PDB 1ivh Chain D

Receptor sequence

>1ivhD (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]

VDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQL
GNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCI
NQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKG
NHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGF
STSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLER
LVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLM
ACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGY
INDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNAD

3D structure

PDB

1ivh Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.

Chain

Resolution

2.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	M135 S136 E254 A375 R387
Catalytic site (residue number reindexed from 1)	M130 S131 E249 A370 R382
Enzyme Commision number	1.3.8.1: short-chain acyl-CoA dehydrogenase. 1.3.8.4: isovaleryl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	D	R280 F283 F290 M293 Q348 G352	R275 F278 F285 M288 Q343 G347
BS02	FAD	D	M135 S136 G141 S142 W166 I167 T168 L370 T377 E379	M130 S131 G136 S137 W161 I162 T163 L365 T372 E374
BS03	COS	D	S142 S190 M248 E254 R255 G374 A375 G376 V380 R387	S137 S185 M243 E249 R250 G369 A370 G371 V375 R382

Gene Ontology

	Molecular Function
GO:0003995	acyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0008470	3-methylbutanoyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006552	L-leucine catabolic process
GO:0006631	fatty acid metabolic process
GO:0009083	branched-chain amino acid catabolic process
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase

	Cellular Component
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1ivh, PDBe:1ivh, PDBj:1ivh
PDBsum	1ivh
PubMed	9214289
UniProt	P26440\|IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial (Gene Name=IVD)

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