Structure of PDB 1ie3 Chain D

Receptor sequence
>1ie3D (length=312) Species: 562 (Escherichia coli) [Search protein sequence]
MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIP
TAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKN
LVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLD
IICSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVA
DLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVE
CAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLK
KDIALGQEFVNK
3D structure
PDB1ie3 Structural Analyses of a Malate Dehydrogenase with a Variable Active Site
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R87 D150 H177
Catalytic site (residue number reindexed from 1) R87 D150 H177
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G10 I12 D34 I35 S76 A77 G78 I97 I117 N119 H177 M227 G10 I12 D34 I35 S76 A77 G78 I97 I117 N119 H177 M227
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase (NAD+) activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0006108 malate metabolic process
GO:0006113 fermentation
GO:0009061 anaerobic respiration
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0019898 extrinsic component of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ie3, PDBe:1ie3, PDBj:1ie3
PDBsum1ie3
PubMed11389141
UniProtP61889|MDH_ECOLI Malate dehydrogenase (Gene Name=mdh)

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