Structure of PDB 1hr8 Chain D

Receptor sequence
>1hr8D (length=443) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ASQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTA
HFLQHLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDI
PKAVDILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEI
TYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHE
KLVQYAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIA
IALEGVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSL
ANSYMSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKIS
DAEVNRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVD
KITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
3D structure
PDB1hr8 Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H70 Q73 H74 E143 E150
Catalytic site (residue number reindexed from 1) H51 Q54 H55 E124 E131
Enzyme Commision number 3.4.24.64: mitochondrial processing peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Q73 F77 N100 A101 Y102 T103 E160 L181 L286 A290 S327 Q379 Q54 F58 N81 A82 Y83 T84 E141 L162 L267 A271 S308 Q360
BS02 ZN D H70 H74 E150 H51 H55 E131
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0017087 mitochondrial processing peptidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hr8, PDBe:1hr8, PDBj:1hr8
PDBsum1hr8
PubMed11470436
UniProtP10507|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)

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