Structure of PDB 1h5t Chain D

Receptor sequence
>1h5tD (length=290) Species: 562 (Escherichia coli) [Search protein sequence]
KMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRD
ILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIG
GDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEF
DKNGTAISLEEKPLEPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEIT
DINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKV
SCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKD
3D structure
PDB1h5t Kinetic and Crystallographic Analyses Support a Sequential-Ordered Bi Bi Catalytic Mechanism for Escherichia Coli Glucose-1-Phosphate Thymidylyltransferase
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.24: glucose-1-phosphate thymidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYD D G219 R220 G221 G218 R219 G220
BS02 TYD D Y115 G116 H117 D118 V251 I257 Y114 G115 H116 D117 V250 I256
BS03 DAU D L9 G11 G12 Q27 Q83 P86 G88 D111 Y146 G147 E162 K163 V173 W224 L8 G10 G11 Q26 Q82 P85 G87 D110 Y145 G146 E161 K162 V172 W223
Gene Ontology
Molecular Function
GO:0008879 glucose-1-phosphate thymidylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009243 O antigen biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1h5t, PDBe:1h5t, PDBj:1h5t
PDBsum1h5t
PubMed11697907
UniProtP37744|RMLA1_ECOLI Glucose-1-phosphate thymidylyltransferase 1 (Gene Name=rfbA)

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