Structure of PDB 1gz6 Chain D

Receptor sequence
>1gz6D (length=301) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGS
SAADKVVEEIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGI
LRDRSFSRISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASA
SGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSRMTE
TVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERT
LGAIVRKRNQPMTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKI
D
3D structure
PDB1gz6 Binary Structure of the Two-Domain (3R)-Hydroxyacyl-Coa Dehydrogenase from Rat Peroxisomal Multifunctional Enzyme Type 2 at 2.38 A Resolution
ChainD
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S151 Y164 K168
Catalytic site (residue number reindexed from 1) S149 Y162 K166
Enzyme Commision number 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase.
4.2.1.107: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase.
4.2.1.119: enoyl-CoA hydratase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI D G16 G20 L21 D40 L41 S75 V76 N99 A100 G101 I102 H123 T149 S151 Y164 K168 P194 A196 S198 R199 M200 G14 G18 L19 D38 L39 S73 V74 N97 A98 G99 I100 H121 T147 S149 Y162 K166 P192 A194 S196 R197 M198
External links
PDB RCSB:1gz6, PDBe:1gz6, PDBj:1gz6
PDBsum1gz6
PubMed12517343
UniProtP97852|DHB4_RAT Peroxisomal multifunctional enzyme type 2 (Gene Name=Hsd17b4)

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