Structure of PDB 1g0o Chain D

Receptor sequence
>1g0oD (length=281) Species: 148305 (Pyricularia grisea) [Search protein sequence]
AVTQPRGESKYDAIPGPLGPQSASLEGKVALVTGAGRGIGREMAMELGRR
GCKVIVNYANSTESAEEVVAAIKKNGSDAACVKANVGVVEDIVRMFEEAV
KIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVAREAYKH
LEIGGRLILMGSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKIT
VNVVAPGGIKTDMYHAVCREYIPNGENLSNEEVDEYAAVQWSPLRRVGLP
IDIARVVCFLASNDGGWVTGKVIGIDGGACM
3D structure
PDB1g0o Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
ChainD
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G40 S164 H175 Y178 K182 Y223
Catalytic site (residue number reindexed from 1) G38 S162 H173 Y176 K180 Y221
Enzyme Commision number 1.1.1.252: tetrahydroxynaphthalene reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP D G36 R39 G40 I41 A61 N62 S63 N87 V88 N114 S115 G116 M162 S164 Y178 K182 P208 G210 I211 T213 M215 G34 R37 G38 I39 A59 N60 S61 N85 V86 N112 S113 G114 M160 S162 Y176 K180 P206 G208 I209 T211 M213
BS02 PYQ D S164 I165 Y178 G210 M215 C220 Y223 S162 I163 Y176 G208 M213 C218 Y221 MOAD: Ki=14nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047039 tetrahydroxynaphthalene reductase activity
Biological Process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1g0o, PDBe:1g0o, PDBj:1g0o
PDBsum1g0o
PubMed11342131
UniProtQ12634|T4HR_PYRO7 Tetrahydroxynaphthalene reductase (Gene Name=MGG_02252)

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