Structure of PDB 1f76 Chain D

Receptor sequence
>1f76D (length=336) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCM
GLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL
FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQ
GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNK
QNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD
RSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS
VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
3D structure
PDB1f76 E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 N111 F115 S175 N177 T178 K217 N246
Catalytic site (residue number reindexed from 1) G85 N111 F115 S175 N177 T178 K217 N246
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D A62 G63 K66 T86 N111 N172 K217 N246 T247 S267 G268 G296 G297 Y318 S319 A62 G63 K66 T86 N111 N172 K217 N246 T247 S267 G268 G296 G297 Y318 S319
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0106430 dihydroorotate dehydrogenase (quinone) activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1f76, PDBe:1f76, PDBj:1f76
PDBsum1f76
PubMed12220493
UniProtP0A7E1|PYRD_ECOLI Dihydroorotate dehydrogenase (quinone) (Gene Name=pyrD)

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